PandemieGrippaleV1, France, Analysis, bibRecord, 000634

H1N1 influenza A virus neuraminidase modulates infectivity in mice

Identifieur interne : 000634 ( France/Analysis ); précédent : 000633; suivant : 000635

H1N1 influenza A virus neuraminidase modulates infectivity in mice

Auteurs : Olivier Ferraris [France] ; Vanessa Escuret [France] ; Maude Bouscambert [France] ; Jean-Sébastien Casalegno [France] ; Frederic Jacquot [France] ; Herve Raoul [France] ; Valérie Caro [France] ; Martine Valette [France] ; Bruno Lina [France] ; Michele Ottmann [France]

Source :

Antiviral research [ 0166-3542 ] ; 2012.

RBID : Pascal:12-0179377

Descripteurs français

Pascal (Inist)
- Exo-α-sialidase, Pouvoir infectant, Animal, Souris, Virus grippal A, Oséltamivir, Modèle animal, Médicament, Pharmacothérapie, Antiviral, Influenzavirus A(H1N1), Grippe pandémique, Réassortiment génétique.
Wicri :
- topic : Médicament.

English descriptors

KwdEn :
- Animal, Animal model, Antiviral, Drug, Exo-α-sialidase, Genetic reassortment, Infectivity, Influenza A virus, Mouse, Oseltamivir, Pharmacotherapy.

Abstract

In the 2 years since the onset of the H1N1 2009 pandemic virus (H1N1pdm09), sporadic cases of oseltamivir-resistant viruses have been reported. We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on viral pathogenicity in mice. Reassortant viruses with the neuraminidase from seasonal H1N1 virus were obtained by co-infection of a H1N1pdm09 virus and an oseltamivir-resistant H1N1 Brisbane-like virus. Oseltamivir-resistant H1N1pdm09 viruses were also isolated from patients. After biochemical characterization, the pathogenicity of these viruses was assessed in a murine model. We confirmed a higher infectivity, in mice, of the H1N1pdm09 virus compared to seasonal viruses. Surprisingly, the oseltamivir-resistant H1N1pdm09 virus was more infectious than its sensitive counterpart. Moreover, the association of H1N1pdm09 hemagglutinin and an oseltamivir-resistant neuraminidase improved the infectivity of reassortant viruses in mice, regardless of the NA origin: seasonal (Brisbane-like) or pandemic strain. This study highlights the need to closely monitor the emergence of oseltamivir-resistant viruses.

Affiliations:

France
Auvergne-Rhône-Alpes, Rhône-Alpes, Île-de-France
Bron, Lyon, Paris

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000711
to stream PascalFrancis, to step Curation: 001725
to stream PascalFrancis, to step Checkpoint: 000620
to stream Main, to step Merge: 002156
to stream Main, to step Curation: 002097
to stream Main, to step Exploration: 002097
to stream France, to step Extraction: 000634

Links to Exploration step

Pascal:12-0179377

Le document en format XML

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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
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<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Lyon <sub>1</sub>
, EA 4610, Laboratoire de Virologie et Pathologie Humaine, Faculté de médecine Laennec</s1>
<s2>69372 Lyon</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre National de Référence Influenzae Région Sud, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon</s1>
<s2>69677 Bron</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Bron</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Casalegno, Jean Sebastien" sort="Casalegno, Jean Sebastien" uniqKey="Casalegno J" first="Jean-Sébastien" last="Casalegno">Jean-Sébastien Casalegno</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Université de Lyon</s1>
<s2>69000 Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Lyon <sub>1</sub>
, EA 4610, Laboratoire de Virologie et Pathologie Humaine, Faculté de médecine Laennec</s1>
<s2>69372 Lyon</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre National de Référence Influenzae Région Sud, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon</s1>
<s2>69677 Bron</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Bron</settlement>
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</affiliation>
</author>
<author><name sortKey="Jacquot, Frederic" sort="Jacquot, Frederic" uniqKey="Jacquot F" first="Frederic" last="Jacquot">Frederic Jacquot</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Laboratoire P4 (BSL4) Jean-Mérieux, INSERM</s1>
<s2>69365 Lyon</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raoul, Herve" sort="Raoul, Herve" uniqKey="Raoul H" first="Herve" last="Raoul">Herve Raoul</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Laboratoire P4 (BSL4) Jean-Mérieux, INSERM</s1>
<s2>69365 Lyon</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caro, Valerie" sort="Caro, Valerie" uniqKey="Caro V" first="Valérie" last="Caro">Valérie Caro</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Plateforme de Génotypage des Pathogenes et Santé Publique, PF8-Génopole, Institut Pasteur</s1>
<s2>75015 Paris</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Valette, Martine" sort="Valette, Martine" uniqKey="Valette M" first="Martine" last="Valette">Martine Valette</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre National de Référence Influenzae Région Sud, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon</s1>
<s2>69677 Bron</s2>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
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<settlement type="city">Bron</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Université de Lyon</s1>
<s2>69000 Lyon</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Lyon <sub>1</sub>
, EA 4610, Laboratoire de Virologie et Pathologie Humaine, Faculté de médecine Laennec</s1>
<s2>69372 Lyon</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre National de Référence Influenzae Région Sud, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon</s1>
<s2>69677 Bron</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Bron</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ottmann, Michele" sort="Ottmann, Michele" uniqKey="Ottmann M" first="Michele" last="Ottmann">Michele Ottmann</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Université de Lyon</s1>
<s2>69000 Lyon</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Université Lyon <sub>1</sub>
, EA 4610, Laboratoire de Virologie et Pathologie Humaine, Faculté de médecine Laennec</s1>
<s2>69372 Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<country>France</country>
<placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Antiviral research</title>
<title level="j" type="abbreviated">Antivir. res.</title>
<idno type="ISSN">0166-3542</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Antiviral research</title>
<title level="j" type="abbreviated">Antivir. res.</title>
<idno type="ISSN">0166-3542</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Animal model</term>
<term>Antiviral</term>
<term>Drug</term>
<term>Exo-α-sialidase</term>
<term>Genetic reassortment</term>
<term>Infectivity</term>
<term>Influenza A virus</term>
<term>Mouse</term>
<term>Oseltamivir</term>
<term>Pharmacotherapy</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Exo-α-sialidase</term>
<term>Pouvoir infectant</term>
<term>Animal</term>
<term>Souris</term>
<term>Virus grippal A</term>
<term>Oséltamivir</term>
<term>Modèle animal</term>
<term>Médicament</term>
<term>Pharmacothérapie</term>
<term>Antiviral</term>
<term>Influenzavirus A(H1N1)</term>
<term>Grippe pandémique</term>
<term>Réassortiment génétique</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médicament</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">In the 2 years since the onset of the H1N1 2009 pandemic virus (H1N1pdm09), sporadic cases of oseltamivir-resistant viruses have been reported. We investigated the impact of oseltamivir-resistant neuraminidase from H1N1 Brisbane-like (seasonal) and H1N1pdm09 viruses on viral pathogenicity in mice. Reassortant viruses with the neuraminidase from seasonal H1N1 virus were obtained by co-infection of a H1N1pdm09 virus and an oseltamivir-resistant H1N1 Brisbane-like virus. Oseltamivir-resistant H1N1pdm09 viruses were also isolated from patients. After biochemical characterization, the pathogenicity of these viruses was assessed in a murine model. We confirmed a higher infectivity, in mice, of the H1N1pdm09 virus compared to seasonal viruses. Surprisingly, the oseltamivir-resistant H1N1pdm09 virus was more infectious than its sensitive counterpart. Moreover, the association of H1N1pdm09 hemagglutinin and an oseltamivir-resistant neuraminidase improved the infectivity of reassortant viruses in mice, regardless of the NA origin: seasonal (Brisbane-like) or pandemic strain. This study highlights the need to closely monitor the emergence of oseltamivir-resistant viruses.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
<li>Île-de-France</li>
</region>
<settlement><li>Bron</li>
<li>Lyon</li>
<li>Paris</li>
</settlement>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Ferraris, Olivier" sort="Ferraris, Olivier" uniqKey="Ferraris O" first="Olivier" last="Ferraris">Olivier Ferraris</name>
</region>
<name sortKey="Bouscambert, Maude" sort="Bouscambert, Maude" uniqKey="Bouscambert M" first="Maude" last="Bouscambert">Maude Bouscambert</name>
<name sortKey="Bouscambert, Maude" sort="Bouscambert, Maude" uniqKey="Bouscambert M" first="Maude" last="Bouscambert">Maude Bouscambert</name>
<name sortKey="Bouscambert, Maude" sort="Bouscambert, Maude" uniqKey="Bouscambert M" first="Maude" last="Bouscambert">Maude Bouscambert</name>
<name sortKey="Caro, Valerie" sort="Caro, Valerie" uniqKey="Caro V" first="Valérie" last="Caro">Valérie Caro</name>
<name sortKey="Casalegno, Jean Sebastien" sort="Casalegno, Jean Sebastien" uniqKey="Casalegno J" first="Jean-Sébastien" last="Casalegno">Jean-Sébastien Casalegno</name>
<name sortKey="Casalegno, Jean Sebastien" sort="Casalegno, Jean Sebastien" uniqKey="Casalegno J" first="Jean-Sébastien" last="Casalegno">Jean-Sébastien Casalegno</name>
<name sortKey="Casalegno, Jean Sebastien" sort="Casalegno, Jean Sebastien" uniqKey="Casalegno J" first="Jean-Sébastien" last="Casalegno">Jean-Sébastien Casalegno</name>
<name sortKey="Escuret, Vanessa" sort="Escuret, Vanessa" uniqKey="Escuret V" first="Vanessa" last="Escuret">Vanessa Escuret</name>
<name sortKey="Escuret, Vanessa" sort="Escuret, Vanessa" uniqKey="Escuret V" first="Vanessa" last="Escuret">Vanessa Escuret</name>
<name sortKey="Escuret, Vanessa" sort="Escuret, Vanessa" uniqKey="Escuret V" first="Vanessa" last="Escuret">Vanessa Escuret</name>
<name sortKey="Ferraris, Olivier" sort="Ferraris, Olivier" uniqKey="Ferraris O" first="Olivier" last="Ferraris">Olivier Ferraris</name>
<name sortKey="Jacquot, Frederic" sort="Jacquot, Frederic" uniqKey="Jacquot F" first="Frederic" last="Jacquot">Frederic Jacquot</name>
<name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<name sortKey="Lina, Bruno" sort="Lina, Bruno" uniqKey="Lina B" first="Bruno" last="Lina">Bruno Lina</name>
<name sortKey="Ottmann, Michele" sort="Ottmann, Michele" uniqKey="Ottmann M" first="Michele" last="Ottmann">Michele Ottmann</name>
<name sortKey="Ottmann, Michele" sort="Ottmann, Michele" uniqKey="Ottmann M" first="Michele" last="Ottmann">Michele Ottmann</name>
<name sortKey="Raoul, Herve" sort="Raoul, Herve" uniqKey="Raoul H" first="Herve" last="Raoul">Herve Raoul</name>
<name sortKey="Valette, Martine" sort="Valette, Martine" uniqKey="Valette M" first="Martine" last="Valette">Martine Valette</name>
</country>
</tree>
</affiliations>
</record>

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H1N1 influenza A virus neuraminidase modulates infectivity in mice

H1N1 influenza A virus neuraminidase modulates infectivity in mice

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